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Chemokine Detection Kits

Chemokines, 8 to 12 kDa proteins, are a sub-class of the cytokine family.  They are classified into four highly conserved groups, sharing 20 to 70 percent of their amino acid sequences.  The alpha and beta-chemokines, which contain four cysteines, are the two major families.  Among alpha chemokines, one amino acid separates the first two cysteine residues (CXC), whereas in the beta chemokines, the first two cysteine residues are adjacent to each other (CC).  There are two minor chemokine groups, one which only has two cysteines (C) and the other which has the first two cysteine residues separated by three amino acids (CXXXC) (1, 2).


Chemokines induce inflammatory cell migration and activation by binding to specific G-protein-coupled cell-surface receptors expressed on different types of leukocytes. The alpha chemokines specifically attract neutrophils, but do not act on lymphocytes.  Conversely, beta chemokines do not act on neutrophils, but selectively attract and activate monocytes and lymphocytes.  In fact, chemokine signaling attracts and accumulates leukocytes in injured or damaged tissues, initiating both acute and chronic inflammatory responses.  Therefore, elevated chemokine levels are observed in many inflammatory diseases (3-5). Furthermore, in malignant cancers, chemokines play roles both in inducing both of immune-cell infiltration, as well as in cancer-cell proliferation (6).


Chondrex, Inc. provides chemokine detection ELISA kits to study the complicated pathological roles of chemokines in systemic inflammatory reactions in many inflammatory diseases and cancer.
 

Human Chemokine Detection Kits

Product Catalog # Price (USD)
Human CCL2 Detection Assay Kit 6821 299.00
Human CCL28 Detection Assay Kit 6824 299.00
Human CCL5 Detection Assay Kit 6822 299.00
Human CXCL1 Detection Assay Kit 6825 299.00

Mouse Chemokine Detection Kits

Product Catalog # Price (USD)
Mouse CCL2 Detection Assay Kit 6721 299.00
Mouse CCL25 Detection Assay Kit 6723 299.00
Mouse CCL5 Detection Assay Kit 6722 299.00
Mouse CXCL1 Detection Assay Kit 6725 299.00
Mouse CXCL14 Detection Assay Kit 6727 299.00

References

1.    L. C. Borish, J. W. Steinke, 2. Cytokines and chemokines. Journal of Allergy and Clinical Immunology. 111, S460–S475 (2003).
2.    A. D. Luster, Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med. 338, 436–445 (1998).
3.    G. E. White, A. J. Iqbal, D. R. Greaves, CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges. Pharmacological Reviews. 65, 47–89 (2013).
4.    P. Proost, A. Wuyts, J. van Damme, The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 26, 211–223 (1996).
5.    C. M. M. Martínez, R. H. Pando, [Chemokines, a new family of cytokines in inflammatory cell recruitment]. Rev. Invest. Clin. 51, 255–268 (1999).
6.    F. Balkwill, Cancer and the chemokine network. Nat Rev Cancer. 4, 540–550 (2004).