Acute phase proteins (APPs) are blood proteins that are an integral part of acute phase responses (APR). The APR is a part of the innate host defense system which is triggered by tissue damage and inflammation caused by infectious, immunologic, or neoplastic agents. Of the well-characterized APPs, C-reactive protein (CRP) and serum amyloid A (SAA) levels are significantly elevated after inflammatory irritation, surgical trauma, or inflammatory diseases, and as such are used for routine testing to detect inflammation in many diseases (1-9).
Chondrex, Inc provides a canine CRP ELISA kit (Catalog # 6027) and a serum feline SAA ELISA detection kit (Catalog # 6028) which can be used to detect and monitor inflammation, as well as in studies investigating inflammation. Furthermore, anti-CRP and SAA monoclonal antibodies are available. Please refer to the product pages for more information.
|Product||Catalog #||Price (USD)|
|Canine CRP Detection Kit||6027||347.00|
|Feline SAA Detection Kit||6028||347.00|
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2. M. Nakamura , M. Takahashi, K. Ohno, A. Koshino, K. Nakashima, et al., C-reactive protein concentration in dogs with various diseases. J Vet Med Sci 70, 127-131 (2008).
3. S. Yamamoto, S. Miyabi, N. Abe, K. Otabe, E. Furukawa, et al., Canine C-reactive protein (CRP) does not share common antigenicity with human CRP. Vet Res Commun 17, 259-266 (1993).
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7. K. Sasaki et al., Evaluation of feline serum amyloid A (SAA) as an inflammatory marker. J. Vet. Med. Sci. 65, 545–548 (2003).
8. T. Tamamoto, K. Ohno, A. Ohmi, Y. Goto-Koshino, H. Tsujimoto, Verification of measurement of the feline serum amyloid A (SAA) concentration by human SAA turbidimetric immunoassay and its clinical application. J. Vet. Med. Sci. 70, 1247–1252 (2008).
9. T. Tamamoto et al., Serum amyloid A as a prognostic marker in cats with various diseases. Journal of Veterinary Diagnostic Investigation. 25, 428–432 (2013).