Acute phase proteins (APPs) are blood proteins that are an integral part of acute phase responses (APR). The APR is a part of the innate host defense system which is triggered by tissue damage and inflammation caused by infectious, immunologic, or neoplastic agents. Of the well-characterized APPs, C-reactive protein (CRP) and serum amyloid A (SAA) levels are significantly elevated after inflammatory irritation, surgical trauma, or inflammatory diseases, and as such are used for routine testing to detect inflammation in many diseases (1-9).
Chondrex, Inc provides a canine CRP ELISA kit (Catalog # 6027) and a serum feline SAA ELISA detection kit (Catalog # 6028) which can be used to detect and monitor inflammation, as well as in studies investigating inflammation. Furthermore, anti-CRP and SAA monoclonal antibodies are available. Please refer to the product pages for more information.
|Product||Catalog #||Price (USD)|
|Canine CRP Detection Kit||6027||347.00|
|Feline SAA Detection Kit||6028||347.00|
4. M. Kjelgaard-Hansen, A. L. Jensen, G. A. Houser, L. R. Jessen, A. T. Kristensen, Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report. Acta Vet Scand 48, 9 (2006).
5. A. Hillström, J. Bylin, R. Hagman, K. Björhall, H. Tvedten, et al., Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs. BMC Vet Res 12, 240 (2016).
8. T. Tamamoto, K. Ohno, A. Ohmi, Y. Goto-Koshino, H. Tsujimoto, Verification of measurement of the feline serum amyloid A (SAA) concentration by human SAA turbidimetric immunoassay and its clinical application. J. Vet. Med. Sci. 70, 1247–1252 (2008).