House dust mite (HDM) is one of the most common asthma allergens, affecting up to 85% of asthma patients (1). More than 20 types of HDM allergens in Dermatophagoides pteronyssinus (Der p) are defined based on sequential and functional homologies. Among these HDM allergens, group 2 (Der p2) is a myeloid differentiation factor 2-related lipid-recognition protein. Der p2 can activate toll-like receptor 4 on respiratory epithelial cells and thus play a role in developing respiratory diseases (2, 3). In mice, Der p2 has been utilized as a potential candidate for allergy vaccine development (4), especially for DNA vaccines (5).
To study the allergen-specific pathological effects and immune response elicited by Der p2 in mouse models of human asthma, Chondrex, Inc. has released new Mouse Anti-Der p2 IgG, IgG2a, IgG2b, and IgM Antibody ELISA Kits (Catalog #3065-3068).
Please also refer to our other HDM allergen antibody ELISA kits for more assays.
1. M. Masoli, D. Fabian, S. Holt, R. Beasley, Global Initiative for Asthma (GINA) Program, The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 59, 469–478 (2004).
2. S. C. Yin, E. C. Liao, C. L. Chiu, C. Y. Chang, J. J. Tsai, Der p2 Internalization by Epithelium Synergistically Augments Toll-like Receptor-Mediated Proinflammatory Signaling. Allergy Asthma Immunol. Res. 7, 393–403 (2015).
3. I.-J. Bau, G.-J. Wang, A Highly Sensitive Electrochemical Impedimetric Nanobiosensor for Dust Mite Antigen Der p2 Detection. ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, 3–9 (201
4. V. B. Joshi, A. Adamcakova-Dodd, X. Jing, A. Wongrakpanich, K. N. Gibson-Corley, P. S. Thorne, A. K. Salem, Development of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergy. AAPS J. 16, 975–985 (2014).
5. G. Li, Z. Liu, N. Zhong, B. Liao, Y. Xiong, Therapeutic effects of DNA vaccine on allergen-induced allergic airway inflammation in mouse model. Cell. Mol. Immunol. 3, 379–384 (2006).