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Mouse - Anti-House Dust Mite Antibody Assays

Asthma is a common chronic inflammatory disease that affects 300 million people of all ages worldwide (1). It is caused by exposure to allergens such as dust mites, pet dander, pollen, or mold, and characterized by airflow obstruction and bronchospasm. House dust mite (HDM) is the most common asthma allergen, which affects up to 85% of asthma patients (2, 3).  Of the two main mite species, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), more than 20 types of HDM allergens are defined based on sequential and functional homologies. Among those HDM allergens, group 1 (Der 1) and group 2 (Der 2) dominate overall allergic responses in patients and are the most commonly researched allergens (4-6).

To study the  and allergen-specific pathological effects and the immune response elicited by HDM allergens in mouse models of human asthma, Chondrex offers a line of Mouse Anti-HDM Antibody Assay Kits. These kits are ideal for assaying serum and plasma samples to quanitfy the levels of IgG, IgG1, IgG2b, IgE and IgM in mouse samples.

If you are a first time buyer of one of these kits, do not forget to ask about our 50% trial discount! Email support@chondrex.com with any questions.

Mouse Anti-HDM Antibody Assay Kits

Product Catalog # Price (USD)
Mouse Anti-House Dust Mite (HDM) IgE Antibody Assay Kit 3037 365.00
Mouse Anti-House Dust Mite (HDM) IgG Antibody Assay Kit 3030 365.00
Mouse Anti-House Dust Mite (HDM) IgG1 Antibody Assay Kit 3034 365.00
Mouse Anti-House Dust Mite (HDM) IgG2b Antibody Assay Kit 3035 365.00
Mouse Anti-House Dust Mite (HDM) IgM Antibody Assay Kit 3036 365.00

References

  1. M. Masoli, D. Fabian, S. Holt, R. Beasley, G. I. f. A. G. Program, The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59, 469-478 (2004).
  2. L. G. Gregory, C. M. Lloyd, Orchestrating house dust mite-associated allergy in the lung. Trends Immunol 32, 402-411 (2011).
  3. V. D. Gandhi, C. Davidson, M. Asaduzzaman, D. Nahirney, H. Vliagoftis, House dust mite interactions with airway epithelium: role in allergic airway inflammation. Curr Allergy Asthma Rep 13, 262-270 (2013).
  4. W. R. Thomas, W. Smith, House-dust-mite allergens. Allergy 53, 821-832 (1998).
  5. A. Custovic, S. C. Taggart, H. C. Francis, M. D. Chapman, A. Woodcock, Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol 98, 64-72 (1996).
  6. A. Jacquet, The role of innate immunity activation in house dust mite allergy. Trends Mol Med 17, 604-611 (2011).