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Mouse - Anti-House Dust Mite Antibody Assays

Asthma is a common chronic inflammatory disease that affects 300 million people of all ages worldwide (1). It is caused by exposure to allergens such as dust mites, pet dander, pollen, or mold, and characterized by airflow obstruction and bronchospasm. House dust mite (HDM) is the most common asthma allergen, which affects up to 85% of asthma patients (2, 3).  Of the two main mite species, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), more than 20 types of HDM allergens are defined based on sequential and functional homologies. Among those HDM allergens, group 1 (Der 1) and group 2 (Der 2) dominate overall allergic responses in patients and are the most commonly researched allergens (4-6).

To study the immune response to allergens and allergen-specific pathological effects in mouse models, Chondrex, Inc. provides a mouse IgG anti-HDM antibody assay kit (Catalog # 3030). Other antibody subtype ELISA kits against HDM Der 1 and Der 2 are currently in development.  Please contact Chondrex, Inc. at  support@chondrex.com for more information.

Mouse Anti-HDM Antibody Assay Kits

Product Catalog # Price (USD)
Mouse Anti-House Dust Mite (HDM) IgG Antibody Assay Kit 3030 365.00

References

  1. M. Masoli, D. Fabian, S. Holt, R. Beasley, G. I. f. A. G. Program, The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59, 469-478 (2004).
  2. L. G. Gregory, C. M. Lloyd, Orchestrating house dust mite-associated allergy in the lung. Trends Immunol 32, 402-411 (2011).
  3. V. D. Gandhi, C. Davidson, M. Asaduzzaman, D. Nahirney, H. Vliagoftis, House dust mite interactions with airway epithelium: role in allergic airway inflammation. Curr Allergy Asthma Rep 13, 262-270 (2013).
  4. W. R. Thomas, W. Smith, House-dust-mite allergens. Allergy 53, 821-832 (1998).
  5. A. Custovic, S. C. Taggart, H. C. Francis, M. D. Chapman, A. Woodcock, Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol 98, 64-72 (1996).
  6. A. Jacquet, The role of innate immunity activation in house dust mite allergy. Trends Mol Med 17, 604-611 (2011).