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Organ Rejection - Type V Collagen

Recently, a concern has been raised that type V collagen may play a role in graft rejection following lung transplants. Chondrex, Inc. provides bovine and human type V collagen for studying the possible involvement of type V collagen immunity in organ allograft rejection in both in vitro and in vivo experiments.

Bovine and Human Type V Collagen

Product Composition Quantity Catalog # Price (USD)
Immunization Grade Bovine Amnion Type V Collagen [alpha1(V)]2 alpha2(V) 1 mg, lyophilized 1092 303.00
Immunization Grade Human Amnion Type V Collagen [alpha1(V)]2 alpha2(V) 1 mg, lyophilized 1095 347.00
Immunization Grade Human Placenta Type V Collagen alpha1(V) alpha2(V) alpha3(V) + [alpha1(V)]2 alpha2(V) 1 mg, lyophilized 10951 347.00

Organ Allograft Rejection
Type V collagen may play a role in graft rejection following lung transplants (See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the  pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39). It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis (58.8%, 10/17) compared to patients who were negative for the DTH reaction (15.8%, 6/38) (Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8).

Type V and Type XI Collagen
Type V collagen is one of the minor collagen components forming interstitial collagen fibrils with type I collagen, and plays a critical role in the regulation of fibrillogenesis. Type V collagen from most tissues consists of two α1(V) and one α2(V) chains, [α1(V)]2α2(V), whereas the placenta contains two subtypes of type V collagen, [α1(V)]2α2(V) and α1(V)α2(V)α3(V). Type V collagen is closely related to type XI collagen consisting of three different alpha chains, α1(XI), α2(XI), and α3(XI), which co-exists with type II collagen in articular cartilage, and regulates fibrillogenesis of type II collagen. Since type V and type XI collagen share nearly 80% homology, type XI collagen may be a suitable reference for assaying antibodies to type V collagen.