The contamination of water and food by pathogenic microorganisms and their toxins is a serious issue for human health and safety (1, 2). Especially, enterotoxins (SEs) produced by Staphylococcus aureus (S. aureus) are highly stable, meaning pathological activity remains even after exposure to sterilization techniques and digestive proteases. Among the SEs, staphylococcal enterotoxin A (SEA) and B (SEB) cause enteritis and food poisoning, together with may involve in the pathogenesis of autoimmune-related diseases (4), such as atopic dermatitis (3, 5), food allergies (6,7), colitis (8, 9), arthritis (6, 10-12), and systemic lupus erythematosus (6, 13).
Lipopolysaccharide (LPS) is a major component of the outer-membrane in gram-negative bacteria. While the main role of LPS is to maintain the integrity of the bacteria envelope, LPS also binds to the CD14/TLR4/MD2 receptor complex on many cell types (14-15), such as B cells, macrophages, and dendritic cells, resulting in pro-inflammatory cytokine release from these cells (16). This activation of the innate immune response causes inflammation which may play important roles in obesity and chronic inflammatory diseases such as Crohn’s Disease, Chronic Fatigue Syndrome, Ulcerative Colitis, and Rheumatoid Arthritis. Translocation of bacteria toxins from intestinal flora may also trigger the pathogenesis of autoimmune diseases (17-18).
Bacterial Toxin Detection Kits
|Product||Catalog #||Price (USD)|
|LPS Detection Kit||6039||375.00|
|Staphylococcal Enterotoxin A (SEA) Detection Kit||6029||347.00|
|Staphylococcal Enterotoxin B (SEB) Detection Kit||6030||347.00|
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