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Bacterial Toxin Detection

The contamination of pathogenic microorganisms and their toxins in food and water is a serious issue for human health and safety (1, 2). Especially, enterotoxins (SEs) produced by Staphylococcus aureus (S. aureus) are highly stable, meaning pathological activity remains even after exposure to sterilization techniques and digestive proteases. Among the SEs, staphylococcal enterotoxin A (SEA) and B (SEB) cause enteritis and food poisoning, together with may involve in the pathogenesis of autoimmune-related diseases (4), such as atopic dermatitis (3, 5), food allergies (6,7), colitis (8, 9), arthritis (6, 10-12), and systemic lupus erythematosus (6, 13). 

Bacterial Toxin Detection Kits

Product Catalog # Price (USD)
Staphylococcal Enterotoxin A (SEA) Detection Kit 6029 347.00
Staphylococcal Enterotoxin B (SEB) Detection Kit 6030 347.00

1. I. Sospedra, C. Soler, J. Mañes, J. M. Soriano, Rapid whole protein quantitation of staphylococcal enterotoxins A and B by liquid 
chromatography/mass spectrometry. J Chromatogr A 1238, 54-59 (2012). 

2. C. Hedberg, Food-related illness and death in the United States. Emerg Infect Dis 5, 840-842 (1999). 

3. N. Kamada, S. U. Seo, G. Y. Chen, G. Núñez, Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 13, 321-335 (2013). 

4. J. Li, J. Yang, Y. Lu, S. Wu, M. Wang, et al., Possible Role of Staphylococcal Enterotoxin B in the Pathogenesis of Autoimmune Diseases. Viral Immunol 28, 354-359 (2015).
5. S. W. Hong, M. Kim, E. Lee, J. Kim, Y. Kim, et al., Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 66, 351-359 (2011). 

6. E. Baharav, H. Gur, P. Fishman, L. Ziporen, M. Blank, et al., Superantigens and experimental SLE induced by idiotypic dysregulation. Clin Exp Rheumatol 14, 359-366 (1996). 

7. K. Ganeshan, C. Neilsen, A. Hadsaitong, R. Schleimer, X. Luo, et al., Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J Allergy Clin Immunol 123, 231-238 e234 (2009). 

8. P. C. Yang, C. S. Wang, Z. Y. An, A murine model of ulcerative colitis: induced with sinusitis-derived superantigen and food allergen. BMC Gastroenterol 5, 6 (2005). 

9. J. Lu, A. Wang, S. Ansari, R. M. Hershberg, D. M. McKay, Colonic bacterial superantigens evoke an inflammatory response and exaggerate disease in mice recovering from colitis. Gastroenterology 125, 1785-1795 (2003). 

10. P. H. Wooley, B. Cingel, Staphylococcal enterotoxin B increases the severity of type II collagen induced arthritis in mice. Ann Rheum Dis 54, 298-304 (1995). 

11. H. Nagai, Y. Takaoka, H. Kamada, H. Mori, The model of arthritis induced by superantigen in mice. Life Sci 55, PL233-237 (1994). 

12. H. Nagai, Y. Takaoka, K. Kuwabara, H. Kamada, K. Kitagaki, The effect of SM-8849 on experimental arthritis in mice. Pharmacology 52, 377-386 (1996). 

13. D. E. Scott, W. J. Kisch, A. D. Steinberg, Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice. J Immunol 150, 664-672 (1993).