Allergic diseases and symptoms arise from an active immune response to antigens which are usually harmless, such as pollen, pet dander, or food. Specifically, food allergies and asthma are two common childhood autoimmune diseases that have affected more individuals recently.
A food allergy is an immune response to foods or food ingredients that most other people can tolerate with no problem. Chicken egg allergy is the second most common food allergy (the first being bovine milk allergy), and is observed in 0.5 to 2.5% of young children. Egg allergy is an immunological reaction induced by egg proteins and is defined as an allergen-specific IgE antibody-mediated allergy, also known as a type I food allergy. Among egg proteins, ovalbumin (OVA) is one of the identified allergenic proteins (1) (2).
Asthma is a chronic inflammatory disease that affects 300 million people of all ages worldwide (3). It is caused by exposure to allergens such as dust mites, pet dander, pollen, or mold, and characterized by airflow obstruction and bronchospasm. House dust mite (HDM) allergens are the most important indoor allergens in humans (3). Approximately 10% of asthma patients sensitized to HDM demonstrate IgE antibodies to the tropomyosin protein (Der p10) from dust mite, Dermatophagoides pteronyssius (2). Der p10 is a 32 kDa, group 10 allergen (tropomyosins). Tropomyosins of a similar structure are found in invertebrates such as crustaceans (shrimp, lobster, crawfish, and crab), arachnids (house dust mites), insects (cockroaches), and mollusks. Tropomyosin is a heat-stable protein and sensitization may lead to severe reactions to the allergenic source. Therefore, the Der p10 antigen may play a role in the cross-induction of allergic reaction to many allergens. (4)
To analyze the pathogenesis of these allergens, OVA and HDM (Der p 10), in allergic reactions in patients or animal disease models, Chondrex, Inc. provides allergen detection ELISA kits: OVA (Cat # 6032) and HDM (Der p 10) (Cat # 6031). For more information, please contact Chondrex, Inc. at firstname.lastname@example.org. Furthermore, anti-OVA and anti-HDM monoclonal antibodies are available. Please refer to the product pages for more information.
Allergic Antigen Detection Assay Kits
|Product||Catalog #||Price (USD)|
|HDM (Der p 10) Detection Assay Kit||6031||347.00|
|Ovalbumin (OVA) Detection Assay Kit||6032||347.00|
1. J. Caubet, J. Wang, Current Understanding of Egg Allergy. Pediatr Clin North Am 58, 427-43, xi (2011).
2. M. Lloyd, Advances in Allergy Testing: Component Resolved Diagnostics. Journal for Clinical Studies, 1–4 (2017).
3. T. Buday, J. Plevkova, House Dust Mite Allergy Models - Reliability for Research of Airway Defensive Mechanisms. OJMIP 04, 27–35 (2014).
4. R. H. Shafique, M. Inam, M. Ismail, F. R. Chaudhary, Group 10 allergens (tropomyosins) from house-dust mites may cause covariation of sensitization to allergens from other invertebrates. Allergy Rhinol (Providence) 3, e74–90 (2012).