Allergic diseases and symptoms arise from an active immune response to normally inocuous antigens, such as pollen, pet dander, or food. Specifically, food allergies and asthma are two common childhood inflammatory diseases that have affected more individuals recently.
A food allergy is an immune response to foods or food ingredients that most other people can tolerate without issue. Chicken egg allergy is the second most common food allergy (the first being bovine milk allergy), and is observed in 0.5 to 2.5% of young children. Egg allergy is an immunological reaction induced by egg proteins and is defined as an allergen-specific IgE antibody-mediated allergic response, also known as a type I food allergy. Among egg proteins, ovalbumin (OVA) is one of the identified allergenic proteins (1) (2).
Asthma is a chronic inflammatory disease that affects 300 million people of all ages worldwide (3). It is caused by exposure to allergens such as dust mites, pet dander, pollen, or mold, and characterized by reversible airway obstruction and bronchospasm. House dust mite (HDM) allergens are the most important indoor allergens in humans (3). Approximately 10% of asthma patients sensitized to HDM demonstrate IgE antibodies to the tropomyosin protein (Der p10) from dust mite, Dermatophagoides pteronyssius (2). Der p10 is a 32 kDa, group 10 allergen (tropomyosins). Tropomyosins of a similar structure are found in invertebrates such as crustaceans (shrimp, lobster, crawfish, and crab), arachnids (house dust mites), insects (cockroaches), and mollusks. Tropomyosin is a heat-stable protein and sensitization may lead to severe reactions to the allergenic source. Therefore, the Der p10 antigen may play a role in the cross-induction of allergic reaction to many allergens. (4)
To analyze the role of OVA and HDM (Der p 10) in allergic reaction pathogensis of human allergies or animal models of allergies, Chondrex, Inc. provides OVA Detection ELISA kits (Cat # 6032) and HDM (Der p 10) Detection ELISA Kits (Cat # 6031). Furthermore, anti-OVA and anti-HDM monoclonal antibodies are available. Please refer to the product pages for more information.
For more information, please contact Chondrex, Inc. at firstname.lastname@example.org.
Allergic Antigen Detection Assay Kits
|Product||Catalog #||Price (USD)|
|HDM (Der p 10) Detection Assay Kit||6031||347.00|
|Ovalbumin (OVA) Detection Assay Kit||6032||347.00|
4. R. H. Shafique, M. Inam, M. Ismail, F. R. Chaudhary, Group 10 allergens (tropomyosins) from house-dust mites may cause covariation of sensitization to allergens from other invertebrates. Allergy Rhinol (Providence) 3, e74–90 (2012).