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Nephritis - Cationic BSA

To effectively study the pathogenesis of nephritis caused by granular subepithelial deposition of IgG immune complexes, a well-characterized nephritis mouse model is required. A new nephritis model induced by immunization with a chemically modified cationic bovine serum albumin (cBSA) may provide an ideal tool for nephritis studies. Chondrex provides cBSA and offers an optimized immunization schedule for effectively inducing nephritis in Balb/c and ICR mice.

Mouse kidneys leak serum components such as bilirubin, resulting in overestimated urinary protein levels when assaying by the turbidity method, thus proteinuria is not a suitable marker for the evaluation of nephritis severity. On the other hand, albumin is the first protein observed in the urine when kidney dysfunction begins to develop, thus it is a more suitable marker for the evaluation of nephritis in mouse models. This kit  employs a sandwich assay method, which requires only 4 hours to complete. In the mouse nephritis model, a mouse is deemed nephritic if the total albumin content in a 16-hour urine collection is greater than 1 mg. It is important to note that urinary albumin levels can reach up to 50-200 mg in a 16-hour urine collection, depending on the severity of nephritis.

Cationic Bovine Serum Albumin

Product Quantity Catalog # Price (USD)
Cationic Bovine Serum Albumin (cBSA) 20 mg (2mg/ml, 10 ml) 9058 83.00

Mouse Urinary Albumin Detection Kit

Product Catalog # Price (USD)
Mouse Albumin Detection Kit 3012 299.00