Dextran sulfate is a common additive in cell culture media where it is often used as an anti-coagulant. Aggregations of cells affects cell growth, nutrient transports, proliferation and obstructs cell counting and monitoring. Dextran sulfate in combination with trypsin was shown to diminish cell-aggregation during culture of Chinese hamster ovary (CHO) cells (1). Dextran sulfate has also shown to inhibit apoptosis and increase protein production in CHO cells (2) when used as an additive in cell media.
Dextran sulfate (low sulfate)
| Product | Quantity | Catalog # | Price (USD) | |
|---|---|---|---|---|
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Dextran sulfate 100kDa LS, 100g | 100 g | CDB015-100g | 981.00 |
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Dextran sulfate 100kDa LS, 10g | 10 g | CDB015-10g | 300.00 |
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Dextran sulfate 10kDa LS, 100g | 100 g | CDB009-100g | 981.00 |
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Dextran sulfate 10kDa LS, 10g | 10 g | CDB009-10g | 300.00 |
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Dextran sulfate 20kDa LS, 100g | 100 g | CDB013-100g | 981.00 |
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Dextran sulfate 20kDa LS, 10g | 10 g | CDB013-10g | 300.00 |
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Dextran sulfate 40kDa LS, 100g | 100 g | CDB003-100g | 981.00 |
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Dextran sulfate 40kDa LS, 10g | 10 g | CDB003-10g | 300.00 |
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Dextran sulfate 500kDa LS, 100g | 100 g | CDB051-100g | 981.00 |
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Dextran sulfate 500kDa LS, 10g | 10 g | CDB051-10g | 300.00 |
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Dextran sulfate 5kDa LS, 100g | 100 g | CDB005-100g | 981.00 |
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Dextran sulfate 5kDa LS, 10g | 10 g | CDB005-10g | 300.00 |
Dextran sulfate (high sulfate)
| Product | Quantity | Catalog # | Price (USD) | |
|---|---|---|---|---|
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Dextran sulfate 100kDa HS, 100g | 100 g | CDB016-100g | 981.00 |
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Dextran sulfate 100kDa HS, 10g | 10 g | CDB016-10g | 300.00 |
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Dextran sulfate 10kDa HS, 100g | 100 g | CDB008-100g | 981.00 |
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Dextran sulfate 10kDa HS, 10g | 10 g | CDB008-10g | 300.00 |
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Dextran sulfate 20kDa HS, 100g | 100 g | CDB012-100g | 981.00 |
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Dextran sulfate 20kDa HS, 10g | 10 g | CDB012-10g | 300.00 |
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Dextran sulfate 500kDa HS, 100g | 100 g | CDB050-100g | 1461.00 |
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Dextran sulfate 500kDa HS, 10g | 10 g | CDB050-10g | 352.00 |
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Dextran sulfate 5kDa HS, 100g | 100 g | CDB004-100g | 981.00 |
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Dextran sulfate 5kDa HS, 10g | 10 g | CDB004-10g | 300.00 |
References
- Y. Jing, C. Zhang, T. Fu, C. Jiang, K. Ma, et al., Combination of dextran sulfate and recombinant trypsin on aggregation of Chinese hamster ovary cells. Cytotechnology 68, 241-8 (2016).
- J. Menvielle, N. Safini, S. Tisminetzky, N. Skoko, Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent. Mol Biotechnol 54, 711-20 (2013).