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Cytokine Detection Assays

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Cytokines are small proteins secreted by a multitude of cell types that participate in autocrine, paracrine or endocrine signaling. Generally, there are two groups of cytokines: pro-inflammatory and anti-inflammatory. 1) Pro-inflammatory cytokines are produced predominantly by activated macrophages and are involved in the up-regulation of inflammatory reactions. These include interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. 2) Anti-inflammatory cytokines regulate the pro-inflammatory cytokine response by repressing the expression of specific cytokines and down-regulating cytokine receptors in an immune response. Key anti-inflammatory cytokines include IL-1 receptor antagonist, IL-4, IL-10, IL-11, and IL-13. Interestingly, leukemia inhibitory factor, interferon-alpha, IL-6, and transforming growth factor (TGF)-β are categorized as either anti-inflammatory or pro-inflammatory cytokines (1,2).

Chondrex, Inc. provides cytokine detection ELISA kits to study the complicated physiological and pathological roles of cytokines in systemic inflammatory reactions in arthritis, nephritis, allergies, and colitis.

Human Cytokine Detection Assays

Product Catalog # Price (USD)
Human Interferon Gamma (IFN gamma) Detection Assay Kit 6804 299.00
Human Interleukin 1 beta (IL-1 beta) Detection Assay Kit 6805 299.00
Human Interleukin 17 (IL-17) Detection Assay Kit 6808 299.00
Human Interleukin 4 (IL-4) Detection Assay Kit 6803 299.00
Human Interleukin 6 (IL-6) Detection Assay Kit 6802 299.00
Human Transforming Growth Factor-beta (TGF-beta) Detection Assay kit 6809 299.00
Human Tumor Necrosis Factor Alpha (TNF-alpha) Detection Assay Kit 6801 299.00
Human Vascular Endothelial Growth Factor (VEGF) Detection Assay Kit 6810 299.00

Mouse Cytokine Detection Assays

Product Catalog # Price (USD)
Mouse Interferon Gamma (IFN gamma) Detection Assay Kit 6704 299.00
Mouse Interleukin 1 beta (IL-1 beta) Detection Assay Kit 6705 299.00
Mouse Interleukin 10 (IL-10) Detection Assay Kit 6706 299.00
Mouse Interleukin 17 (IL-17) Detection Assay Kit 6708 299.00
Mouse Interleukin 2 (IL-2) Detection Assay Kit 6711 299.00
Mouse Interleukin-4 (IL-4) Detection Assay Kit 6703 299.00
Mouse Interleukin-6 (IL-6) Detection Assay Kit 6702 299.00
Mouse Transforming Growth Factor - beta 1 (TGF-beta 1) Detection Kit 6709 299.00
Mouse Tumor Necrosis Factor Alpha (TNF-alpha) Detection Assay Kit 6701 299.00
Mouse Vascular Endothelial Growth Factor (VEGF) Detection Assay Kit 6710 299.00

References

  1. Dinarello, Charles A. Proinflammatory cytokines. Chest journal 118.2: 503-508 (2000).
  2. Opal, Steven M., and Vera A. DePalo. Anti-inflammatory cytokines. Chest Journal 117.4: 1162-1172 (2000).