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Inflammatory Bowel Disease - DSS-Induced Colitis

Inflammatory bowel disease is a multifactorial disease with unknown etiology, and is comprised of two major subtypes, ulcerative colitis (UC) and Crohn’s disease (CD).  UC affects mostly the large intestine or colon, while CD may affect any part of the gastrointestinal tract (1).  To study UC, dextran sulfate sodium (DSS) is frequently used to induce colitis in experimental animals since an acute, chronic, or relapsing colitis can be easily induced by changing the concentration or administration period of DSS (2).

Chondrex provides DSS for the induction of colitis in experimental animals, as well as simple tools for evaluating typical features and complications of disease, which mimic human colitis (3, 4).  The following results show the evaluation of a DSS-induced mouse colitis model in C3H mice by measuring A) body weight, B) hemoglobin (hb) levels (a marker of anemia) and C) gastrointestinal permeability with FITC-dextran.

Dextran Sulfate Sodium for Colitis

Product Quantity Catalog # Price (USD)
Dextran Sulfate Sodium for Colitis 20 g 4015 250.00


Experimental Protocol
C3H Mice (Female, 7-8 weeks old)
3.5% DSS in water or water only ad libitum, Day 1 - Day 5

REFERNCES

1.    R. Boismenu, Y. Chen, Insights from mouse models of colitis. J Leukoc Biol 67, 267-278 (2000).
2.    M. Perse, A. Cerar, Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol 2012, 718617 (2012).
3.    Y. Yan et al., Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS One 4, e6073 (2009).
4.    P. R. Carter et al., Iron status, anemia, and plasma erythropoietin levels in acute and chronic mouse models of colitis. Inflamm Bowel Dis 19, 1260-1265 (2013).