Andrographolide, a component of the medicinal plant Andrographis paniculata, is a bioactive compound with many biological effects ranging from anti-inflammatory to anti-tumor activities. In a recent study, an andrographolide derivative conjugated with lipoic acid, termed AL-1, was evaluated for its ability to treat a the DSS-Induced Colitis Model of ulcerative colitis (UC). Not only could AL-1 reduce the disease severity, it helped to resolve a key feature that drives the intestinal inflammation characteristic of the DSS-colitis model. This research has promising results for new therapeutics to treat human UC.
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