Arthrogen-CIA® 5-Clone Cocktail Kit, 40 mg

Catalog No.
40 mg (*20 mice)

Quote Request


Arthrogen-CIA® arthritogenic monoclonal antibody 5 clones cocktail kit (40 mg, 10 mg/ml x 4 ml) + LPS

Mouse CAIA (Chinese version)
Mouse CAIA Protocol

A. Balkrishna, S. Sakat, K. Joshi, S. Paudel, D. Joshi, et al., Anti-Inflammatory and Anti-Arthritic Efficacies of an Indian Traditional Herbo-Mineral Medicine "Divya Amvatari Ras" in Collagen Antibody-Induced Arthritis (CAIA) Mouse Model Through Modulation of IL-6/IL-1β/TNF-α/NFκB Signaling. Front Pharmacol 10, 659 (2019).

Ahmad SF et al., STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. Immunobiology 222(2):206-217, (2017). PMID: 27717524

Atkinson S et al., Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis inC57BL/6 mice that can be counteracted by IL-17 blockade. Dis Model Mech 9, 427-40, (2016). PMID: 26822477

Biscetti F et al., The role of high‐mobility group box protein 1 in collagen antibody-induced arthritis is dependent on vascular endothelial growth factor . Clin Exp Immunol 184, 62-72, (2016). PMID: 26671547

Danks L et al., RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Ann Rheum Dis 75, 1187-95, (2016). PMID: 26025971

Fukumitsu S et al., Anti-inflammatory and anti-arthritic effects of pentacyclic triterpenoids maslinic acid through NF-κBinactivation. Mol Nutr Food Res 60, 399-409, (2016). PMID: 26499467

Hirota K et al., Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. Immunity 48(6):1220-1232.e5. (2018). PMID: 29802020

Ishikawa J et al., Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis. Bone 83, 210-9, (2016). PMID: 26603475

Jubair WK et al., Modulation of Inflammatory Arthritis in Mice by Gut Microbiota Through Mucosal Inflammation and Autoantibody Generation. Arthritis & Rheumatology 70(8):1220-1233, (2018). PMID: 29534332

Katayama M et al., Ficolin-1 is a promising therapeutic target for autoimmune diseases. International Immunology 31, 23-32, (2019). PMID: 30169661

Maruyama K et al., Bone-protective Functions of Netrin 1 Protein. J Biol Chem 291(46):23854-23868, (2016). PMID: 27681594

Matsuo Y et al., Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis. Biochem Biophys Res Commun 470, 504-9, (2016). PMID: 26806309

Park H et al., The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. Eur J Pain 20, 917-25, (2016). PMID: 26517300

Peng J et al., Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p. Arthritis Rheumatol 68, 370-81, (2016). PMID: 26473405

M. Cantley, D. Fairlie, P. Bartold, V. Marino, P. Gupta, D. Haynes, et al., Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology (Oxford) 54, 1713-23 (2015).

E. Perilli, M. Cantley, V. Marino, T. Crotti, M. Smith, et al., Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography. Scand J Immunol 81, 142-50 (2015).

J. Su, T. Gao, T. Shi, Q. Xiang, X. Xu, et al., Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model. J Comp Neurol 523, 1505-28 (2015).

E. Rossato, M. Ben, Y. Kanamaru, M. Hurtado-Nedelec, G. Hayem, et al., Reversal of arthritis by human monomeric IgA through receptor mediated SHP-1 inhibitory pathway. Arthritis Rheumatol 67, 1766-77 (2015).

T. Endo, K. Ito, J. Morimoto, M. Kanayama, D. Ota, et al., Syndecan-4 regulates the development of autoimmune arthritis by modulating B cell migration and germinal center formation. Arthritis Rheumatol 67, 2512-22 (2015).

C. Hansell, L. MacLellan, R. Oldham, J. Doonan, K. Chapple, et al., The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunol Cell Biol 93, 167-76 (2015).

S. Atkinson, A. Nansen, P. Usher, B. Sondergaard, C. Mackay, et al., Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. Autoimmunity 48, 460-70 (2015).

J. Lee, E. Hong, H. Jeong, J. Hwang, H. Kim, et al., A novel histone deacetylase 6-selective inhibitor suppresses synovial inflammation and joint destruction in a collagen antibody-induced arthritis mouse model. Int J Rheum Dis 18, 514-23 (2015).

F. Tseng, W. Chia, C. Wang, J. Shyu, G. Gou, et al., Carbon Monoxide Inhibits Receptor Activator of NF-?B (RANKL)-Induced Osteoclastogenesis. Cell Physiol Biochem 36, 1250-8 (2015).

D. Kim, D. Lee, M. Jo, D. Son, M. Park, et al., Exacerbation of Collagen Antibody-Induced Arthritis in Transgenic Mice Overexpressing Peroxiredoxin 6. Arthritis Rheumatol 67, 3058-69 (2015).

M. Donoviel, N. Hait, S. Ramachandran, M. Maceyka, K. Takabe, et al., Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases. FASEB J 29, 5018-28 (2015).

T. Okano, T. Koike, M. Tada, Y. Sugioka, K. Mamoto, et al., Hyperleptinemia suppresses aggravation of arthritis of collagen-antibody-induced arthritis in mice. J Orthop Sci 20, 1106-13 (2015).

N. Gully, R. Bright, V. Marino, C. Marchant, M. Cantley, et al., Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One 9, e100838 (2014).

M. Drutskaya, G. Efimov, R. Zvartsev, A. Chashchina, D. Chudakov, et al., Experimental models of arthritis in which pathogenesis is dependent on TNF expression. Biochemistry (Mosc) 79, 1349-57 (2014).

M. Ebbesen, K. Bienk, B. Deleuran, K. Howard, Extended blood circulation and joint accumulation of a p(HPMA-co-AzMA)-based nanoconjugate in a murine model of rheumatoid arthritis. Mol Cell Ther 2, 9 (2014).

N. Agalave, M. Larsson, S. Abdelmoaty, J. Su, A. Baharpoor, et al., Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis. Pain 155, 1802-13 (2014).

Y. Sun, P. Caplazi, J. Zhang, A. Mazloom, S. Kummerfeld, et al., PILRα Negatively Regulates Mouse Inflammatory Arthritis. J Immunol 193, 860-70 (2014).

S. Kon, Y. Nakayama, N. Matsumoto, K. Ito, M. Kanayama, et al., A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for a9ß1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis. PLoS One 9, e116210 (2014).

I. Campbell, S. Miescher, D. Branch, P. Mott, A. Lazarus, et al., Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils. J Immunol 192, 5031-8 (2014).

A. Abd-Allah, S. Ahmad, I. Alrashidi, H. Abdel-Hamied, K. Zoheir, et al., Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis. Int Immunol 26, 325-40 (2014).

R. Zhao, N. Chen, X. Zhou, P. Miao, C. Hu, et al., Exogenous IFN-beta regulates the RANKL-c-FosIFN-beta signaling pathway in the collagen antibody-induced arthritis model. J Transl Med 12, 330 (2014).

S. Funato, A. Matsunaga, K. Oh, Y. Miyamoto, K. Yoshimura, et al., Effects of antibody to receptor activator of nuclear factor ?-B ligand on inflammation and cartilage degradation in collagen antibody-induced arthritis in mice. J Negat Results Biomed 13, 18 (2014).

H. Zhou, H. Yan, H. Pan, K. Hou, A. Akk, et al., Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. J Clin Invest 124, 4363-74 (2014).

G. Mehta, V. Ferreira, C. Skerka, P. Zipfel, N. Banda, New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol 62, 235-48 (2014).

R. Zhao, N. Chen, X. Zhou, P. Miao, C. Hu, et al., Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model. J Transl Med 12, 330 (2014).

B. Crielaard, C. Rijcken, L. Quan, d. van, I. Altintas, et al., Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl 51, 7254-8 (2012).

D. Xu, Y. Kim, J. Postelnek, M. Vu, D. Hu, et al., RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J Pharmacol Exp Ther 341, 90-103 (2012).

T. Chiba, Y. Matsuzaka, T. Warita, T. Sugoh, K. Miyashita, et al., NFKBIL1 Confers Resistance to Experimental Autoimmune Arthritis Through the Regulation of Dendritic Cell Functions. Scand J Immunol 73, 478-85 (2011).

V. Willis, A. Gizinski, N. Banda, C. Causey, B. Knuckley, et al., N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol 186, 4396-404 (2011).

J. Song, I. Hwang, K. Cho, M. Garcia, A. Kim, et al., Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J Clin Invest 121, 3517-27 (2011).

J. Kong, S. Yoo, H. Kim, H. Kim, K. Yea, et al., Inhibition of Synovial Hyperplasia, Rheumatoid T Cell Activation, and Experimental Arthritis in Mice by Sulforaphane, a Naturally Occurring Isthiocyanate. Arthritis Rheum 62, 159-70 (2010).

D. Auci, K. Mangano, D. Destiche, S. White, Y. Huang, et al., Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis. Int J Mol Med 25, 625-33 (2010).

J. Minaguchi, T. Oohashi, K. Inagawa, A. Ohtsuka, Y. Ninomiya, Transvascular accumulation of Sialyl Lewis X conjugated liposome in inflamed joints of collagen antibody-induced arthritic (CAIA) mice. Arch Histol Cytol 71, 195-203 (2008).



Join Our Mailing List