Storage dust mites (SDM) are commonly found in stored foods such as grain, flour, and hay. They are known to cause symptoms such as bronchial asthma, allergic rhinitis, and conjunctivitis, particularly in rural work environments. SDM thrive in warm, humid conditions with an optimum relative humidity of 80% and temperatures between 25 and 30°C.
Asthma and other respiratory diseases caused by sensitization to dust mites are global health problems. In human patients, researchers have identified five IgE-binding components in Acarus siro extracts with molecular weights ranging from 15 to 22 kDa. Among the allergens from Acarus siro group 13 allergens are fatty acid-binding proteins with a molecular weight of 15 kDa. These proteins bind and transport fatty acids (1) and are recognized by 23% of patients with Acarus siro-related allergies (2).
In animal studies, exposure of rats to Acarus siro feces significantly increased serum levels of IFN-gamma and IgE compared to controls. The treated rats also had lower serum IL-4 levels and a higher percentage of eosinophils and basophils in the leukocyte differential count (3).
To study the immune response to allergens and allergen-specific pathological effects in mouse models, Chondrex, Inc. provides mouse anti-Acarus siro antibody ELISA kits. Chondrex, Inc. also offers ELISA kits for assaying other mite and mite-allergen antibody subtypes/subclasses and total immunoglobulin subtypes/subclasses.
Mouse Anti-Acarus siro Antibody Assay Kits
| Product | Catalog # | Price (USD) | |
|---|---|---|---|
 |
Mouse Anti-Acarus siro IgG Antibody Assay Kit | 3097 | 417.00 |
 |
Mouse Anti-Acarus siro IgG1 Antibody Assay Kit | 3098 | 417.00 |
 |
Mouse Anti-Acarus siro IgG2a Antibody Assay Kit | 3099 | 417.00 |
 |
Mouse Anti-Acarus siro IgM Antibody Assay Kit | 3100 | 417.00 |
References
- T. Eriksson, P. Whitley, E. Johansson, H. van, G. Gafvelin, Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins. Int Arch Allergy Immunol 119(4), 275-81 (1999).
- C. Luczynska, P. Griffin, R. Davies, M. Topping, Prevalence of specific IgE to storage mites (A. siro, L. destructor and T. longior) in an urban population and crossreactivity with the house dust mite (D. pteronyssinus). Clin Exp Allergy 20(4), 403-6 (1990).
- B. Abdel-Salam, Seasonal population of Acarus siro mites and effects of their faeces on allergenic immunological disorder modulated by garlic in albino rat. Allergol Immunopathol (Madr) 40(3), 144-51 (2012).