Autoantibodies to type II collagen play a primary role in inducing autoimmune-mediated inflammatory arthritis in the CIA model, but autoantibodies are not always capable of inducing arthritis. In mice, complement fixable IgG2a and IgG2b subtype autoantibody levels are pertinent in the induction of arthritis, as well as their epitope specificity. In order to adequately study the pathological roles of antibodies to type II collagen, Chondre, Inc. provides mouse anti-collagen IgG subtype (IgG1, IgG2a, IgG2b, IgG2c, and IgG3) antibody assay kits for further detailed analysis of antibodies in the mouse CIA model.
Mouse Anti-Type II Collagen IgG1 Subtype Antibody Assay Kit
Mouse Anti-Type II Collagen IgG2a Subtype Antibody Assay Kit
Mouse Anti-Type II Collagen IgG2b Subtype Antibody Assay Kit
Mouse Anti-Type II Collagen IgG2c Subtype Antibody Assay Kit
Mouse Anti-Type II Collagen IgG3 Subtype Antibody Assay Kit
Mouse Anti-Type II Collagen IgG Subtype Assay Kit Protocol
Mouse Anti-Type II Collagen IgG Subtype Assay Kit with TMB Protocol
In order to adequately study the pathological roles of antibodies to type II collagen in mouse CIA model, it is important to determine individual IgG subtype autoantibody levels to mouse type II collagen as well as the antibody levels to the heterologous type II collagen used for immunization.
A standard mouse kit with one species of collagen will measure 39 samples. Each kit contains a reference standard and reagents to perform two partial assays. Customized kits to measure antibody levels to various species of type I and type II collagen can be custom ordered.