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Dextran Sulfates

Dextran sulfate is a common additive in cell culture media where it is often used as an anti-coagulant. Aggregations of cells affects cell growth, nutrient transports, proliferation and obstructs cell counting and monitoring. Dextran sulfate in combination with trypsin was shown to diminish cell-aggregation during culture of Chinese hamster ovary (CHO) cells (1). Dextran sulfate has also shown to inhibit apoptosis and increase protein production in CHO cells (2) when used as an additive in cell media.

Dextran sulfate (low sulfate)

Product Quantity Catalog # Price (USD)
Dextran sulfate 5kDa LS, 10g 10 g CDB005-10g 300.00
Dextran sulfate 5kDa LS, 100g 100 g CDB005-100g 981.00
Dextran sulfate 10kDa LS, 10g 10 g CDB009-10g 300.00
Dextran sulfate 10kDa LS, 100g 100 g CDB009-100g 981.00
Dextran sulfate 20kDa LS, 10g 10 g CDB013-10g 300.00
Dextran sulfate 20kDa LS, 100g 100 g CDB013-100g 981.00
Dextran sulfate 40kDa LS, 10g 10 g CDB003-10g 300.00
Dextran sulfate 40kDa LS, 100g 100 g CDB003-100g 981.00
Dextran sulfate 100kDa LS, 10g 10 g CDB015-10g 300.00
Dextran sulfate 100kDa LS, 100g 100 g CDB015-100g 981.00
Dextran sulfate 500kDa LS, 10g 10 g CDB051-10g 300.00
Dextran sulfate 500kDa LS, 100g 100 g CDB051-100g 981.00

Dextran sulfate (high sulfate)

Product Quantity Catalog # Price (USD)
Dextran sulfate 5kDa HS, 10g 10 g CDB004-10g 300.00
Dextran sulfate 5kDa HS, 100g 100 g CDB004-100g 981.00
Dextran sulfate 10kDa HS, 10g 10 g CDB008-10g 300.00
Dextran sulfate 10kDa HS, 100g 100 g CDB008-100g 981.00
Dextran sulfate 20kDa HS, 10g 10 g CDB012-10g 300.00
Dextran sulfate 20kDa HS, 100g 100 g CDB012-100g 981.00
Dextran sulfate 100kDa HS, 10g 10 g CDB016-10g 300.00
Dextran sulfate 100kDa HS, 100g 100 g CDB016-100g 981.00
Dextran sulfate 500kDa HS, 10g 10 g CDB050-10g 352.00
Dextran sulfate 500kDa HS, 100g 100 g CDB050-100g 1461.00

References

  1. Y. Jing, C. Zhang, T. Fu, C. Jiang, K. Ma, et al., Combination of dextran sulfate and recombinant trypsin on aggregation of Chinese hamster ovary cells. Cytotechnology 68, 241-8 (2016).
  2. J. Menvielle, N. Safini, S. Tisminetzky, N. Skoko, Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent. Mol Biotechnol 54, 711-20 (2013).