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Collagen Induced Arthritis– Adjuvants

Collagen-Induced Arthritis (CIA) can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. To effectively induce CIA in animals, the type of adjuvant used for emulsifying collagen is a key element. Chondrex, Inc. provides both Incomplete Freund’s Adjuvant (IFA) and Complete Freund’s Adjuvant (CFA) containing various amounts of M. tuberculosis to optimize the immunization condition for inducing CIA.

**Please consult with your institution's animal care and use committee before ordering**

Note: For inducing CIA in rats, please use Incomplete Freund's Adjuvant for the emulsion preparation.  Rats are susceptible to adjuvant-induced arthritis (AIA) when immunized with CFA, which leads to the development of a histologically and immunologically distinct type of arthritis than the CIA model. 

Incomplete and Complete Freund's Adjuvant for CIA

Product Content of M. Tuberculosis H-37 RA Quantity Catalog # Price (USD)
Complete Freund's Adjuvant, 1 mg/ml 1 mg/ml 5 ml 7008 31.00
Complete Freund's Adjuvant, 2 mg/ml 2 mg/ml 5 ml 7009 36.00
Complete Freund's Adjuvant, 3 mg/ml 3 mg/ml 5 ml 7015 41.00
Complete Freund's Adjuvant, 4 mg/ml 4 mg/ml 5 ml 7001 54.00
Complete Freund's Adjuvant, 5 mg/ml 5 mg/ml 5 ml 7023 73.00
Incomplete Freund's Adjuvant ----------- 5 ml 7002 28.00

Muramyl Dipeptide, MDP

Product Catalog # Price (USD)
Muramyl Dipeptide, MDP, 2 mg 9065 74.00

Further information: Mouse CIA, and Rat CIA Protocols