Collagen-Induced Arthritis (CIA) can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. To effectively induce CIA in animals, the type of adjuvant used for emulsifying collagen is a key element. Chondrex, Inc. provides both Incomplete Freund’s Adjuvant (IFA) and Complete Freund’s Adjuvant (CFA) containing various amounts of M. tuberculosis to optimize the immunization condition for inducing CIA.
**Please consult with your institution's animal care and use committee before ordering**
Note: For inducing CIA in rats, please use Incomplete Freund's Adjuvant for the emulsion preparation. Rats are susceptible to adjuvant-induced arthritis (AIA) when immunized with CFA, which leads to the development of a histologically and immunologically distinct type of arthritis than the CIA model.
Incomplete and Complete Freund's Adjuvant for CIA
|Product||Content of M. Tuberculosis H-37 RA||Quantity||Catalog #||Price (USD)|
|Complete Freund's Adjuvant, 1 mg/ml||1 mg/ml||5 ml||7008||31.00|
|Complete Freund's Adjuvant, 2 mg/ml||2 mg/ml||5 ml||7009||36.00|
|Complete Freund's Adjuvant, 3 mg/ml||3 mg/ml||5 ml||7015||41.00|
|Complete Freund's Adjuvant, 4 mg/ml||4 mg/ml||5 ml||7001||54.00|
|Complete Freund's Adjuvant, 5 mg/ml||5 mg/ml||5 ml||7023||73.00|
|Incomplete Freund's Adjuvant||-----------||5 ml||7002||28.00|
Muramyl Dipeptide, MDP
|Product||Catalog #||Price (USD)|
|Muramyl Dipeptide, MDP, 2 mg||9065||74.00|