Nephritogenic Monoclonal Antibodies

Chondrex provides three rat monoclonal antibodies against rat glomerular basement membrane, which induce nephritis in certain strains of rats. This nephritis is used as a model for Goodpasture Syndrome, severe renal disease often associated with pulmonary hemorrhage, which is mediated by autoantibodies against glomerular basement membrane. These monoclonal antibodies recognize non-collagenous domain 1 (NC1) of α4 chain of type IV collagen and deposit along the glomerular basement membrane. Individual monoclonal antibodies induce mild to severe nephritis in rats within 1-2 days by a single IP or IV injection.

1) Monoclonal antibody, b35 (IgG2b), induces severe nephritis associated with hematuria and pulmonary hemorrhage.

2) Monoclonal antibody, a84 (IgG2a), induces severe nephritis associated with hematuria.

3) Monoclonal antibody, 114 (IgG1), induces mild nephritis at the same dose of b35 and a84.

Pricing

Nephritogenic Monoclonal Antibodies
Catalog #	Description	Size	Price
70201	Nephritogenic monoclonal antibody 114	1 mL x 1 mg/mL	$650
70205	Nephritogenic monoclonal antibody 114	5 mL x 1 mg/mL	$3200
70211	Nephritogenic monoclonal antibody a84	1 mL x 1 mg/mL	$650
70215	Nephritogenic monoclonal antibody a84	5 mL x 1 mg/mL	$3200
70221	Nephritogenic monoclonal antibody b35	1 mL x 1 mg/mL	$650
70225	Nephritogenic monoclonal antibody b35	5 mL x 1 mg/mL	$3200

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