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Arthrogen-CIA®
Highly Purified Type I & II Collagen
Immunization
Grade Collagen and Adjuvant
 Collagen-induced
arthritis (CIA) shares both immunological and pathological
features with human rheumatoid arthritis (RA), therefore it has
been used extensively as a model to study the pathogenesis of RA
and for testing therapeutics. Chondrex provides various species of highly purified Arthrogen-CIA®
type II collagen for the induction of arthritis in animal models, supplied
in lyophilized or solution form.
Susceptibility
to CIA is dependent upon
the species of type II collagen used for immunization as shown
in the table below (see references 1
& 2),
and is also linked to MHC class II molecules.
| Susceptibility
to CIA in mice, rats, and monkeys depends on both MHC haplotypes
and species of type II collagen used for immunization.
|
Species
of Type II
Collagen |
Mouse |
Rat |
Primate
Monkey
(Outbred) |
DBA/1
(H-2q) |
B10.RIII
(H-2r) |
LOU
(RT1u) |
Lewis
(RT1i) |
| Chicken |
+++ |
- |
+++ |
++ |
+++ |
| Bovine |
+++ |
+++ |
+++ |
+++ |
+++ |
| Porcine |
+++ |
+++ |
+++ |
+++ |
Not Determined |
| Human |
++ |
- |
+ |
+ |
++ |
Pricing
|
Immunization
Grade Type II Collagen |
| Catalog
# |
Species |
Supplied
As |
Form |
Price
|
| 2001-1 |
Chicken |
10
mg/vial |
Lyophilized |
$182 |
| 2001-2 |
2 mg/ml,
5 ml/vial |
Solution |
$182 |
| 2002-1 |
Bovine |
10
mg/vial |
Lyophilized |
$182 |
| 2002-2 |
2 mg/ml,
5 ml/vial |
Solution |
$182 |
| 2003-1 |
Porcine |
10
mg/vial |
Lyophilized |
$182 |
| 2003-2 |
2 mg/ml,
5 ml/vial |
Solution |
$182 |
| 2004-1 |
Rat |
5
mg/vial |
Lyophilized |
$283 |
| 2004-2 |
2 mg/ml,
2.5 ml/vial |
Solution |
$283 |
| 2005-1 |
Human |
1
mg/vial |
Lyophilized |
$300 |
| 2005-2 |
2 mg/ml,
0.5 ml/vial |
Solution |
$300 |
| 2006-1 |
Mouse
|
1
mg/vial |
Lyophilized |
$153 |
| 2006-2 |
2 mg/ml,
0.5 ml/vial |
Solution |
$153 |
|
Arthrogen-CIA®
Adjuvant |
| Catalog
# |
Description |
Supplied
As |
Price
|
|
7001 |
Complete
Freund's Adjuvant
4 mg/ml M. tuberculosis |
5
ml/vial |
$39 |
|
7002 |
Incomplete
Freund's Adjuvant |
5 ml/vial |
$20 |
| 7008
|
Complete
Freund's Adjuvant
1 mg/ml M. tuberculosis |
5 ml/vial |
$22 |
|
7009
|
Complete
Freund's Adjuvant
2 mg/ml M. tuberculosis |
5 ml/vial |
$26 |
| 7015
|
Complete
Freund's Adjuvant
3 mg/ml M. tuberculosis |
5 ml/vial |
$30 |
| 7023
|
Complete
Freund's Adjuvant
5 mg/ml M. tuberculosis |
5 ml/vial |
$46 |
|
Type II collagen solutions are added to an equal volume of the
Arthrogen-CIA® Adjuvant to produce a complete optimized emulsion
for the induction of collagen-induced arthritis in mice.
|
| Immunization
Grade Type I Collagen |
| Catalog
# |
Species |
Supplied
As |
Form |
Price
|
| 1061 |
Chicken |
10
mg/vial |
Lyophilized |
$119 |
| 1062 |
Bovine |
10
mg/vial |
Lyophilized |
$119 |
| 1062-2 |
2 mg/ml,
5 ml/vial |
Solution |
$119 |
| 1063 |
Porcine |
10
mg/vial |
Lyophilized |
$119 |
| 1064 |
Rat |
5 mg/vial |
Lyophilized |
$170 |
| 1064-2 |
2 mg/ml,
2.5 ml/vial |
Solution |
$170 |
| 1065 |
Human |
1 mg/vial |
Lyophilized |
$258 |
| 1066 |
Mouse |
5
mg/vial |
Lyophilized |
$170 |
ELISA
Grade
 CIA
animals generate high levels of antibody to autologous type II collagen.
To assay antibody levels, highly purified type II collagen from various species
is available.
This collagen is specially prepared for coating
ELISA plates and is supplied as a 100x concentrated solution. Each vial
contains enough collagen to coat ten, 96 well plates. To prevent fibril
formation, 10X dilution buffer is also supplied. Also available are complete type II collagen antibody ELISA
kits.
Type I
collagen, which has very high homology to type II collagen, from various
species is also available to determine the cross-reactivity of
antibodies to this collagen type.
|
ELISA
Grade Type
II Collagen |
| Catalog
# |
Source |
Supplied
As |
Price
|
| 2011 |
Chicken |
0.5
mg/vial, 1 ml/vial |
$157 |
| 2012 |
Bovine |
0.5
mg/vial, 1 ml/vial |
$157 |
| 2013 |
Porcine |
0.5
mg/vial, 1 ml/vial |
$157 |
| 2014 |
Rat |
0.5
mg/vial, 1 ml/vial |
$190 |
| 2015 |
Human |
0.5
mg/vial, 1 ml/vial |
$313 |
| 2016 |
Mouse |
0.5
mg/vial, 1 ml/vial |
$450 |
| 2017 |
Monkey |
0.5
mg/vial, 1 ml/vial |
$200 |
|
ELISA
Grade Type
I Collagen |
| Catalog
# |
Source |
0.5
mg/vial, 1 ml/vial |
Price
|
| 1001 |
Chicken |
0.5
mg/vial, 1 ml/vial |
$78 |
| 1002 |
Bovine |
0.5
mg/vial, 1 ml/vial |
$78 |
| 1003 |
Porcine |
0.5
mg/vial, 1 ml/vial |
$78 |
| 1004 |
Rat |
0.5
mg/vial, 1 ml/vial |
$103 |
| 1005 |
Human |
0.5
mg/vial, 1 ml/vial |
$258 |
| 1006 |
Mouse |
0.5
mg/vial, 1 ml/vial |
$103 |
T-Cell Proliferation Grade
Since type II
collagen is a T-cell dependent antigen, T-cell proliferation can be
assayed using ultra-pure, pepsin-free Arthrogen-CIA® T-cell
proliferation grade type II collagen.
|
T-Cell
Proliferation
Grade Type II Collagen |
| Catalog
# |
Source |
Supplied
As |
Price
|
| 2021 |
Chicken |
0.5
mg/vial, lyophilized |
$157 |
| 2022 |
Bovine |
0.5
mg/vial, lyophilized |
$157 |
| 2023 |
Porcine |
0.5
mg/vial, lyophilized |
$157 |
| 2024 |
Rat |
0.5
mg/vial, lyophilized |
$190 |
| 2025 |
Human |
0.5
mg/vial, lyophilized |
$313 |
| 2026 |
Mouse |
0.5
mg/vial, lyophilized |
$450 |
| 2027 |
Monkey |
0.5
mg/vial, lyophilized |
$200 |
|
T-Cell
Proliferation Grade Type I Collagen |
| Catalog
# |
Source |
0.5
mg/vial, lyophilized |
Price
|
| 1051 |
Chicken |
0.5
mg/vial, lyophilized |
$75 |
| 1052 |
Bovine |
0.5
mg/vial, lyophilized |
$75 |
| 1053 |
Porcine |
0.5
mg/vial, lyophilized |
$75 |
| 1054 |
Rat |
0.5
mg/vial, lyophilized |
$100 |
| 1055 |
Human |
0.5
mg/vial, lyophilized |
$250 |
| 1056 |
Mouse |
0.5
mg/vial, lyophilized |
$100 |
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