Arthrogen-CIA® Antibody

Arthrogen-CIA® Arthritogenic Monoclonal Antibodies

(Collagen Antibody-Induced Arthritis - CAIA)

Collagen-induced arthritis is an antibody mediated disease. Therefore, type II collagen specific antibodies can be used to induce arthritis. Arthrogen-CIA^® type II collagen specific antibodies, which when given in combination, induce severe arthritis (see references 5 & 6). The advantage of the monoclonal antibody-induced (mAb) arthritis model is multifold. First, severe arthritis is induced within 24-48 hours instead of the four weeks required to induce arthritis after immunization with type II collagen. Secondly, unlike the collagen-induced model which requires a restricted MHC haplotype, the mAb model can be induced in all strains of mice. Thus, this model is ideal for rapidly screening therapeutics for the treatment of arthritis and to study the mechanisms involved in the development of arthritis.

Advantages

• Reduce the timeline of experiments to 1/10 of the classic collagen-induced arthritis (CIA) model.

• Various strains of mice can be used besides CIA susceptible mice: DBA/1J, B10.RIII, Balb/c, C.B-17 scid/scid, C57BL/6, C57BL/6 backcrossed to 129/Sv and various gene knockout mice.

Applicability

• Rapid screening of anti-inflammatory compounds.

• Evaluating the role of individual genes in the development of arthritis using gene knockout mice.

• Investigating inflammatory mediators and factors such as bacterial and viral toxins.

Histopathology of Control Joint and mAb-Induced Arthritis in CAIA

Arthrogen-CIA® Arthritogenic Monoclonal Antibody
Catalog #	mAb Cocktail/LPS	Price
10010	10 mg Kit	$520
10040	40 mg Kit	$1960
10100	100 mg Kit	$4675

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