CartCollagen Induced Arthritis - Adjuvants
Collagen-induced arthritis (CIA) can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. To effectively induce CIA in animals, the type of adjuvant used for emulsifying collagen is a key element. Chondrex provides six types of Incomplete Freund’s Adjuvant (IFA) and Complete Freund’s Adjuvant (CFA) containing various amounts of M. tuberculosis to optimize the immunization condition for inducing CIA.
Incomplete and Complete Freund's Adjuvant for CIA
| Product | Content of M. Tuberculosis H-37 RA | Quantity | Catalog # | Price (USD) |
| Complete Freund's Adjuvant, 1 mg/ml | 1 mg/ml | 5 ml | 7008 | 24.00 |
| Complete Freund's Adjuvant, 2 mg/ml | 2 mg/ml | 5 ml | 7009 | 28.00 |
| Complete Freund's Adjuvant, 3 mg/ml | 3 mg/ml | 5 ml | 7015 | 32.00 |
| Complete Freund's Adjuvant, 4 mg/ml | 4 mg/ml | 5 ml | 7001 | 42.00 |
| Complete Freund's Adjuvant, 5 mg/ml | 5 mg/ml | 5 ml | 7023 | 57.00 |
| Incomplete Freund's Adjuvant | ----------- | 5 ml | 7002 | 22.00 |
Further information: Mouse CIA, and Rat CIA Protocols
NOTE 1: IFA is used for inducing CIA in rats that are susceptible to CFA and develop Adjuvant- Induced Arthritis (AIA). The optimal concentration of M. tuberculosis for inducing CIA varies depending on the mouse strain and immunization schedule.
NOTE 2: Please consult with your institution's animal care and use committee before ordering.