Collagen Arthritis - Adjuvants

Collagen-induced arthritis (CIA) can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. To effectively induce CIA in animals, the type of adjuvant used for emulsifying collagen is a key element. Chondrex provides six types of Incomplete Freund’s Adjuvant (IFA) and Complete Freund’s Adjuvant (CFA) containing various amounts of M. tuberculosis to optimize the immunization condition for inducing CIA.

Incomplete and Complete Freund's Adjuvant for CIA

Product Content of M. Tuberculosis H-37 RA Quantity Catalog # Price (USD)
Complete Freund's Adjuvant, 1 mg/ml 1 mg/ml 5 ml 7008 30.50
Complete Freund's Adjuvant, 2 mg/ml 2 mg/ml 5 ml 7009 35.70
Complete Freund's Adjuvant, 3 mg/ml 3 mg/ml 5 ml 7015 39.90
Complete Freund's Adjuvant, 4 mg/ml 4 mg/ml 5 ml 7001 52.50
Complete Freund's Adjuvant, 5 mg/ml 5 mg/ml 5 ml 7023 71.40
Incomplete Freund's Adjuvant ----------- 5 ml 7002 27.30

Further information: Mouse CIA, and Rat CIA Protocols

NOTE 1: IFA is used for inducing CIA in rats that are susceptible to CFA and develop Adjuvant- Induced Arthritis (AIA). The optimal concentration of M. tuberculosis for inducing CIA varies depending on the mouse strain and immunization schedule.
NOTE 2: Please consult with your institution's animal care and use committee before ordering.